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| Name | Optical Defibrillation |
| Video Uploader | Video From Johns Hopkins University |
| Upload Date | This Video Uploaded At 13-09-2016 15:40:00 |
| Video Discription | Light Tames Lethal Heart Disorders in Mice and Virtual Humans In Lab Tests, Researchers Halt Arrhythmias With Gentle Beams—Not Harsh Electric Shocks Using high-tech human heart models and mouse experiments, scientists at Johns Hopkins and Germany’s University of Bonn have shown that beams of light could replace electric shocks in patients reeling from a deadly heart rhythm disorder. The findings, published online Sept. 12 in the October 2016 edition of The Journal of Clinical Investigation, could pave the way for a new type of implantable defibrillators. Current devices deliver pulses of electricity that are extremely painful and can damage heart tissue. Light-based treatment, the Johns Hopkins and Bonn researchers say, should provide a safer and gentler remedy for patients at high risk of arrhythmia, an irregular heartbeat that can cause sudden cardiac death within minutes. http://releases.jhu.edu/2016/09/12/light-tames-lethal-heart-disorders-in-mice-and-virtual-humans/ Transcript of video follows: [heart beats above bouncy music] [Natalia Trayanova: We're working towards what we believe is the holy grail.] Achieving an optical defibrillation of the heart where a gentle light will be given to a patient and will completely restore the normal functioning of the heart. Patrick Boyle: A typical electrical defibrillation shock acts very quickly [and almost violently excites the heart terminating the arrhythmia rapidly.] [defibrillator discharging] [Boyle: What we observed in the optogenetic defibrillation process was a gradual slowing of] the arrhythmia which eventually led to termination but without the abrupt punch of a typical electrical defibrillation shock. [heart beat] [Trayanova: Our collaborators at the University of Bonn were able] to embed light sensitive proteins [in the mouse heart that respond to the light that is delivered to the heart. And that successfully results in the termination of the arrhythmia.] [heart beat] [Trayanova: My lab conducted simulations to show that the arrhythmia in the] much larger human heart can be defibrillated [Trayanova: in the same approach.] Trayanova: So you can see this patient has infarct. [Boyle: We used an actual patient model reconstructed from MRI scans of a patient who had a a heart attack and was actually vulnerable to arrhythmia.] So what we discovered was that in order to work in the human heart, [Boyle: ostensibly we would need to use red light which is a longer wavelength and is going to penetrate much deeper in the thicker walls of the human heart.] [Trayanova: We're able to offline in the virtual heart to] figure out what is the best option to go forward in terms of what is [the delivery of the light and what is the best way to achieve a certain distribution of these light sensitive proteins.] [Trayanova: But, this is the big initial step that demonstrates that this is possible.] [music ends] [heart beat] tXpPyrBsPaU |
| Category | Education |
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