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| Name | Aging, and the Life of Fat with Dr. Ben Bikman |
| Video Uploader | Video From Insulin IQ |
| Upload Date | This Video Uploaded At 13-03-2024 20:38:34 |
| Video Discription | In this episode of The Metabolic Classroom, Professor Ben Bikman, a biomedical scientist specializing in diabetes, metabolism, and fat tissue, delves deeper into the topic of fat tissue, focusing specifically on its storage locations and the factors influencing them. Dr. Bikman emphasizes the complexity and nuance of fat tissue beyond its commonly recognized role in energy storage, insulation, and cushioning, highlighting its function as an endocrine organ that produces various hormones and signals. Ben begins by discussing the enzyme lipoprotein lipase (LPL), which plays a crucial role in fat storage by pulling fats off circulating triglyceride-rich lipoproteins in the bloodstream. He explains how the expression and activity of LPL are influenced by factors such as insulin, exercise, and sex hormones, particularly testosterone and estrogen. The lecture explores how sex differences play a significant role in fat storage patterns, with males tending to store fat centrally around the abdomen due to increased LPL expression induced by testosterone, while females typically store more fat in subcutaneous depots such as the breasts, buttocks, and hips, influenced by estrogen. Ben also discusses the impact of menopause on fat storage, noting shifts towards central fat deposition in women as estrogen levels decline. Additionally, Dr. Bikman touches on the effects of aging on fat storage, explaining how fat cell number tends to plateau in adulthood and decrease in older age, leading to hypertrophy (enlargement) of existing fat cells and potentially ectopic fat deposition in organs like the liver and pancreas. The lecture concludes with Ben addressing the difference between hyperplasia (increased fat cell number) and hypertrophy (increased fat cell size) in subcutaneous and visceral fat depots, emphasizing the metabolic implications of storing fat in different locations. He also briefly mentions the influence of non-caloric signals, such as chemicals leached from plastics, on fat cell growth. Overall, the lecture provides a comprehensive overview of the multifaceted nature of fat tissue storage, highlighting the interplay of hormonal, physiological, and environmental factors in shaping fat distribution and its metabolic consequences. 00:01 - Introduction to Fat Tissue and Lipoprotein Lipase (LPL) 01:14 - Overview of Fat Storage and Influencing Factors 02:12 - Review of Subcutaneous and Visceral Fat Deposition 04:07 - Role of Lipoprotein Lipase (LPL) in Fat Storage 05:16 - Influence of Insulin and Exercise on LPL Activity 06:30 - Effect of Sex Hormones on Fat Distribution 07:43 - Puberty and Fat Storage Differences Between Genders 08:50 - Impact of Androgens and Estrogens on LPL Expression 10:00 - Hormonal Changes During Menopause and Fat Storage Shifts 11:52 - Estrogen's Influence on Female Fat Distribution 13:10 - Estrogen's Effect on Fat Storage and Metabolism 14:21 - Menopause and Changes in Fat Distribution 15:18 - Shifts in Fat Storage Patterns with Aging 16:21 - Reduction in Fat Cell Number During Elderly Age 17:49 - Overview of Fat Storage During Infancy and Childhood 18:50 - Transition from Hyperplasia to Hypertrophy in Adulthood 20:02 - Hypertrophy and Its Consequences for Fat Cells 21:30 - Visceral Fat Hypertrophy and Pro-inflammatory Effects 23:35 - Difference Between Hyperplasia and Hypertrophy in Fat Storage 24:25 - Subcutaneous Fat Hyperplasia and Female Fat Distribution 25:33 - Metabolic Implications of Subcutaneous and Visceral Fat Storage 26:42 - Visceral Fat's Increased Sensitivity to Fat-Burning Signals 28:02 - Influence of Non-Caloric Signals on Fat Cell Growth 29:02 - Impact of Plastics on Fat Storage 30:09 - Conclusion and Summary of Key Points #insulinresistance #metabolicsyndrome #metabolichealth #type2diabetes #type1diabetes #weightloss #intermittentfasting #intermittantfasting #fasting #lowcarb Learn more at: https://www.insuliniq.com mJL6WoBAKzk |
| Category | Science & Technology |
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