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| Name | How Zinc Deficiencies Negatively Affect the Immune System |
| Video Uploader | Video From Thomas DeLauer |
| Upload Date | This Video Uploaded At 06-07-2020 16:00:12 |
| Video Discription | Join my Email List: https://www.thomasdelauer.com/life-optimization-tactics/ Get MY Recommendation on Groceries Delivered to Your Doorstep with Thrive Market: http://ThriveMarket.com/Thomas This video does contain a paid partnership with a brand that helps to support this channel. It is because of brands like this that we are able to provide the content that we do for free. The best way that you can directly support my channel, is by supporting the brands that help make this all possible. Any product that you see on my channel is a product that I also use personally, regardless of any paid promotion. Get my Free Newsletter and Downloadable Cheatsheets (eating out, travel, etc): https://www.thomasdelauer.com/life-optimization-tactics/ Follow More of My Daily Life on Instagram: http://www.Instagram.com/ThomasDeLauer It's important that I am honest and to say that this video does have a sponsorship from Thrive Market, supporting them is a good way to support my channel! How Zinc Deficiencies Negatively Affect the Immune System- Thomas DeLauer Zinc and Immune System Anti-inflammatory potential of zinc Inflammation is the major hallmark of innate immunity. One of the major inflammatory pathways is NF-kB. It was reported in the Nutrition that zinc can supress NF-kB by stimulating protein A20. This protein is recognized as anti-inflammatory molecule that prevents modulation of NF-kB by IKK. NF-kB is a transcription factor for many pro-inflammatory cytokines. Two of these cytokines, IL-1beta and TNF alfa, were found to be suppressed after zinc supplementation. As reported in American Journal of Clinical Nutrition. Protein A20 is not the only mediator of zinc’s anti-inflammatory properties. PPAR is well-known in fasting community as it upregulates enzymes needed for fat metabolism in times of nutritional challenge. The expression of PPAR is stimulated by zinc. NF-kB acts by binding to DNA and dictates which part of the DNA should be expressed. PPAR inhibits the binding of NF-KB to DNA and prevents the activation of pro-inflammatory genes. Granulocytes To examine the importance of zinc, researchers are using zinc chelators which disable the utilization of zinc. Study published in Biological Trace Element Research proved that ZD is detrimental for granulocytes functioning. However, zinc excess was shown to impair the function as well. These results signify the importance of correct dosing. The production of ROS is dependent on enzyme NADPH. Zinc is an inhibitor of NADPH and prevents excessive damage from ROS. On the contrary, excessive zinc concentrations can block the capacity to produce ROS and impair the elimination of the pathogen. Macrophages Zinc has an important regulatory function in cells of the innate immunity, particularly in macrophages. The NF-kB is in the centre of the mechanism again. After activation of NF-kB expression of zinc transporter ZIP8 is increased. More zinc can get to the cell and as mentioned earlier, zinc is preventing the binding of NF-kB to DNA and reduces the expression of pro-inflammatory cytokines. Natural Killer Cells Natural killer (NK) cells make up 15% of immune cells in peripheral blood. They can recognize virally infected cell or cancer cell. For optimal functioning of the organism these cells must be destroyed, hence the “killer” name. Immune cells are dependent on communication between each other. NK cells are stimulated by cytokine IL-2 secreted by T cell. In a study published in the Journal of Laboratory and Clinical Medicine, the production of IL-2 is decreased during ZD, resulting in the compromised activity of NK cells. Membrane Barriers Immunity our cells don't depend not only on cells, same as soldiers (immune cells) defending a castle are dependent on a fortress, our body is dependent on the barrier of epithelial cells of lungs and intestine. The epithelium is a series of cell bound tightly to each other to prevent the entry of foreign particles. The close contact of these cells is dependent on protein complexes called tight junctions and adherens junctions. In the study from the Journal of Nutrition, in zinc deprived cells, faster degradation of two structural proteins, E-cadherin and β-catenin, was observed. Supplementation can restore the integrity and function of membrane barriers. References https://pubmed.ncbi.nlm.nih.gov/21035309/ https://pubmed.ncbi.nlm.nih.gov/20427734/ https://pubmed.ncbi.nlm.nih.gov/26400651/ https://pubmed.ncbi.nlm.nih.gov/15451058/ https://pubmed.ncbi.nlm.nih.gov/11038490/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615478/ https://pubmed.ncbi.nlm.nih.gov/6604771/ https://pubmed.ncbi.nlm.nih.gov/19043799/ https://pubmed.ncbi.nlm.nih.gov/18716167/ https://pubmed.ncbi.nlm.nih.gov/72960/ https://pubmed.ncbi.nlm.nih.gov/24647797/ https://pubmed.ncbi.nlm.nih.gov/19474155/ https://link.springer.com/article/10.1007/s00394-015-1100-1 https://pubmed.ncbi.nlm.nih.gov/12660937/ https://pubmed.ncbi.nlm.nih.gov/17595415/ d-3TgXmDiAU |
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